In November 2023, we announced an updated collaboration with our established partner, Bayer, for a select set of precision oncology programs. The collaboration will leverage our state-of-the-art capabilities to initiate and advance the identification of novel therapeutic targets for challenging oncology indications with high unmet need. Under the terms of the agreement, we may initiate up to seven oncology programs and Recursion is eligible to receive potential, success-based, future payments of up to $1.5 billion plus royalties on net sales.
In December 2021, we entered into a multi-year, strategic collaboration with Roche and Genentech in key areas of neuroscience and an oncology indication. Through the partnership, we are working with both Roche and Genentech's R&D units to leverage our Recursion OS and Maps of Biology, along with extensive single-cell perturbation screening data from Roche and Genentech, to rapidly identify novel biological relationships to initiate and advance therapeutic programs. Together we may initiate up to 40 programs over a decade or longer.
In July 2023, we entered into a strategic collaboration with NVIDIA to accelerate the development of our groundbreaking AI foundation models for biology and chemistry on NVIDIA DGX™ Cloud. We intend to optimize and distribute these models for possible commercial license or release on BioNeMo, NVIDIA’s cloud service for generative AI in drug discovery. In November 2023, we committed to working with NVIDIA to expand BioHive-1, our on-premise supercomputer, to increase the computational capacity by over 4x. We project that upon completion and benchmarking, BioHive-1 will be in the top 50 most powerful supercomputers in the world across any industry (according to the Top500 list) and will be the most powerful supercomputer owned and operated by any biopharma company.
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In November 2023, we entered into a collaboration with Tempus to gain preferred access to one of the world’s largest proprietary, de-identified, patient-centric oncology datasets, spanning DNA, RNA, health records and more to support the discovery of potential biomarker-enriched therapeutics at scale through the training of causal AI models. By combining the forward genetics approach of Tempus with the reverse genetics approach at Recursion, we believe we have an opportunity to improve the speed, precision and scale of therapeutic development in oncology.
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In December 2023, we entered into a collaboration with Enamine to generate and design enriched compound libraries for the global drug discovery industry. By leveraging Recursion’s MatchMaker tool to identify compounds in the Enamine REAL Space predicted to bind to high-value targets, the companies believe they can generate more powerful compound libraries for drug discovery purposes. Enamine may offer the resulting libraries to customers for purchase and will co-brand any libraries under both the Enamine and MatchMaker trademarks.
In order to achieve our mission, we partner with leading biotechnology companies, pharmaceutical companies and academic research institutions to identify novel therapeutics and unlock biological insights using our discovery technology. Our partnering efforts take two primary forms: discovery platform partnerships and asset development partnerships.
In addition to NCEs, the Recursion Map may discover new uses for known chemical entities owned or controlled by third parties. In such circumstances, we may in-license rights to these assets to advance these programs internally.
We have collaborated with third parties to broadly explore diverse disease domains (e.g., fibrosis, neuroscience, and oncology). Collaborations leverage our partner's deep domain expertise and Recursion's unique capability to map and navigate complex biology to identify and rapidly advance potential therapeutics.
Connect with us at partner@recursionpharma.com.
Interested in partnering with Recursion? Connect with us at partner@recursionpharma.com.
In December 2021, we entered into a multi-year, strategic collaboration with Roche and Genentech in key areas of neuroscience and an oncology indication. Through the partnership, we are working with both Roche and Genentech's R&D units to leverage our Recursion OS and Maps of Biology, along with extensive single-cell perturbation screening data from Roche and Genentech, to rapidly identify novel biological relationships to initiate and advance therapeutic programs. Together we may initiate up to 40 programs over a decade or longer.
In November 2023, we announced an updated collaboration with our established partner, Bayer, for a select set of precision oncology programs. The collaboration will leverage our state-of-the-art capabilities to initiate and advance the identification of novel therapeutic targets for challenging oncology indications with high unmet need. Under the terms of the agreement, we may initiate up to seven oncology programs and Recursion is eligible to receive potential, success-based, future payments of up to $1.5 billion plus royalties on net sales.
Merck KGaA, Darmstadt, Germany
In September 2023, we entered into a collaboration with Merck KGaA, Darmstadt, Germany. This multi-year collaboration utilizes our AI-driven precision drug design and discovery capabilities while leveraging Merck KGaA, Darmstadt, Germany’s disease expertise in oncology and immunology, clinical development capabilities, and global footprint.
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In January 2022, we entered into a strategic research collaboration with Sanofi to develop an AI-driven pipeline of precision-engineered, small molecule medicines. Through this collaboration, we are using our end-to-end integrated platform to discover and advance up to 15 novel targets in the oncology and immunology therapeutic areas. As part of this agreement, we received an upfront cash payment of $100 million, with the potential to receive up to $5.2 billion in total aggregate milestone payments plus tiered royalties.
In September 2021, we expanded our relationship with the Gates Foundation to develop small molecule therapeutics to help prepare for future pandemics. Building on smaller collaborations in the anti-infective and non-hormonal contraceptive space, we are focusing on programs targeting influenza, coronaviruses, and paramyxoviruses (e.g., Nipah). As part of this collaboration, the Gates Foundation made a $35 million equity investment into Exscientia.
The Bill & Melinda Gates Foundation is a funder of anti-infective programs
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In 2019, we entered into a co-development and co-ownership joint venture with Rallybio to investigate treatments for patients with rare diseases. Following an assessment by our AI platform for biological pathway relevance and chemical druggability risks, the joint venture selected a target, ENPP1. Targeting ENPP1 offers a differentiated approach to current standard of care options for patients with hypophosphatasia (HPP). HPP is a rare, potentially life-threatening genetic disease, characterized by impaired mineralization of bones and teeth. Rallybio’s vital therapeutic area and clinical knowledge allows us to enter this therapeutic area of high unmet need.
Technology
In July 2023, we entered into a strategic collaboration with NVIDIA to accelerate the development of our groundbreaking AI foundation models for biology and chemistry on NVIDIA DGX™ Cloud. We intend to optimize and distribute these models for possible commercial license or release on BioNeMo, NVIDIA’s cloud service for generative AI in drug discovery. In November 2023, we committed to working with NVIDIA to expand BioHive-1, our on-premise supercomputer, to increase the computational capacity by over 4x. We project that upon completion and benchmarking, BioHive-1 will be in the top 50 most powerful supercomputers in the world across any industry (according to the Top500 list) and will be the most powerful supercomputer owned and operated by any biopharma company.
Data
In November 2023, we entered into a collaboration with Tempus to gain preferred access to one of the world’s largest proprietary, de-identified, patient-centric oncology datasets, spanning DNA, RNA, health records and more to support the discovery of potential biomarker-enriched therapeutics at scale through the training of causal AI models. By combining the forward genetics approach of Tempus with the reverse genetics approach at Recursion, we believe we have an opportunity to improve the speed, precision and scale of therapeutic development in oncology.
Learn More
Data
In May 2024, Recursion entered into a multi-year agreement with Helix to access hundreds of thousands of de-identified records including Helix’s Exome+® genomic data and data from longitudinal health records. Recursion plans to use this data to train causal AI models and design biomarker and patient stratification strategies across broad disease areas. The Helix dataset expands Recursion's integration of real-world patient data and complements Recursion's access to Tempus' oncology data.
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Capability
In December 2023, we entered into a collaboration with Enamine to generate and design enriched compound libraries for the global drug discovery industry. By leveraging Recursion’s MatchMaker tool to identify compounds in the Enamine REAL Space predicted to bind to high-value targets, the companies believe they can generate more powerful compound libraries for drug discovery purposes. Enamine may offer the resulting libraries to customers for purchase and will co-brand any libraries under both the Enamine and MatchMaker trademarks.
Learn More
In order to achieve our mission, we partner with leading biotechnology companies, pharmaceutical companies and academic research institutions to identify novel therapeutics and unlock biological insights using our discovery technology. Our partnering efforts take two primary forms: discovery platform partnerships and asset development partnerships.
In addition to NCEs, the Recursion Map may discover new uses for known chemical entities owned or controlled by third parties. In such circumstances, we may in-license rights to these assets to advance these programs internally.
We have collaborated with third parties to broadly explore diverse disease domains (e.g., fibrosis, neuroscience, and oncology). Collaborations leverage our partner's deep domain expertise and Recursion's unique capability to map and navigate complex biology to identify and rapidly advance potential therapeutics.
